Background: EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Positive Control: EBV infected tissues and cells.
Purification Method: Ammonium Sulfate Precipitation.
Source: Sheep were immunized with recombinant EBNA-3A protein.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: Bhattacharjee, Shaoni & Bose, Priyanka & Patel, Krishna & Ghosh Roy, Shatadru & Gain, Chandrima & Gowda, Harsha & Robertson, Erle & Saha, Abhik. (2018). Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death & Disease. 9. 10.1038/s41419-018-0668-9.
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UniProt: Q69138 (EBV/HHV4).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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