Background: Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
Positive Control: Rat or mouse retinal tissue lysate.
Source: Antibody raised in sheep against a recombinant protein corresponding to amino acids 1 to 131 derived from the N-terminal region of the human Chx10 protein conjugated to KLH.
Specificity: Human Chx10 protein.
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7. Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao
Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
https://doi.org/10.1186/s13024-018-0287-z
8. Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease
Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5824-5835. doi:10.1167/iovs.18-2549.
UniProt: P58304.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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