Sheep anti Human p53

Sheep anti Human p53, Polyclonal, IgG

Background: P53 is a transcription factor with a molecular weight of 53kDa that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein.

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Source: Sheep were immunized with a GST-p53 fusion protein containing amino acids 1-393 of human p53

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

UniProt: P04637

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• SKU: EXAA145P
• Manufacturer: Exalpha Biologicals Inc
• Manufacturer SKU: A145P
• Package Unit: 250 µg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Isotype: IgG
• Host: Sheep
• Conjugate: Unconjugated