Background: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.
Positive Control: 293 cells transfected with Dab-1–HA tag.
Immunogen: Recombinant protein corresponding to amino acids 399-555 of mouse disabled coupled to a GST fusion protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as a 0.2um sterile filter solution in phosphate buffered saline with 0.08% sodium azide.
References: 1.Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515
2.Rice,d.s. et.al. (1998) Development 125 ,3710-3729.
UniProt: P97318 (Mouse).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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