Background: Double stranded RNA specific adenosine deaminase 1 (ADAR1 or DRADA) is an enzyme involved in the editing of mammalian messenger RNAs by the site specific conversion of adenosine to inosine. ADAR 1 is thought to play a role in the editing of transcripts encoding non-NMDA glutamate receptor subunits, the 2C subtype of serotonin receptor, as well as hepatitis delta virus antigen.
Purification Method: Antigen Immunoaffiinity Purification.
Source: Sheep were immunized with a GST fusion protein containing amino acid 1116-1176 of the rat DRADA coding sequence. The fusion protein was constructed in the pGEX-KG vector by inserting a fragment corresponding to nucleotides +3346 through +3525 of DRADA at the XbaI and XhoI sites in the vector.
References: 1. Yang, J. -H., et al. 'Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation.' J. Biol. Chem. 2003, 278, 45833-45842
2. Wang, Q., et al. 'Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.' J. Biol. Chem. 2004, 279, 4952-4961
3. Yang, W., et al. 'ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.' J. Biol. Chem. 2005, 280, 3946-3953.
UniProt: P55266 (Rat).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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