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Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Description: Signal regulatory proteinalpha (SIRP-α), also known as Tyrosineprotein phosphatase non-receptor type substrate 1, CD172a, Bit, and MyD-1, GenBank Accession No. NP_542970, a.a. 27-370, with C-terminal Avi and His tags, MW 40.3 kDa*, expressed in a HEK293 expression system and enzymatically biotinylated using Avi-tag™ technology. This protein acts as a receptor for CD47; a.a. 27-370 correspond to the extracellular portion of SIRP-α. *Note: SIRP-α is heavily glycosylated, resulting in higher molecular weight.
Format: Aqueous buffer solution
Formulation: 8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol.
Genbank: NP_542970
Host Cell Line: HEK293
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-Avi-Tags
Uniprot: P78324
Warnings: Avoid freeze/thaw cycles. Protein may be diluted to ≥100 µg/ml in PBS + glycerol and stored at -80°C.
Biosafety Level: Not applicable (BSL-1)
References: 1. Hatherley, D., et al., Mol. Cell, 2008, 31:266-77
2. Baba, N., et al., J. Exp. Med., 2013, 210(6):1251-63
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