SMC5 Polyclonal Antibody, Rabbit

Abbreviation: SMC5

Target Synonym: SMC5;SMC5L1

Conjugation: Unconjugated

UNIProt ID: Q8IY18

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human SMC5

Dilution: WB 1:1000-1:3000

• SKU: ELSE-AB-92465-200
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92465-200
• Green Labware: No
• Package Unit: 200 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit