SR 4835, CAS 2387704-62-1

Formulation: A solid

Formal Name: N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine

Purity: ≥98%

Formula Markup: C21H20Cl2N10O

Formula Weight: 499,4

Shelf life (days): 1460

CAS Number: 2387704-62-1

Notes: SR 4835 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13.{72086} It binds to Cdk12 and Cdk13 (Kds = 98 and 4.9 nM, respectively) and inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 = 105.5 nM). SR 4835 inhibits the proliferation of MDA-MB-231, MDA-MB-468, Hs 578T, and MDA-MB-436 breast cancer cells (EC50s = 15.5, 22.1, 19.9, and 24.9 nM, respectively). It induces the DNA damage response and apoptosis in MDA-MB-231 cells when used at concentrations ranging from 30 to 90 nM. In vivo, SR 4835 (20 mg/kg) reduces tumor volume and decreases the number of mice with tumors greater than 1,000 mm3 in a patient-derived xenograft (PDX) model of breast cancer.

• SKU: CAY39158-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39158-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK