Target: Sulfotyrosine
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: 12B11 (Formerly sold as 7C5)
Immunogen: Synthetic Sulfotyrosine conjugated to Keyhole Limpet Hemocyanin (KLH).
Purification: Protein G Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Specific for sulfated tyrosine residues on various proteins. Does not detect free Sulfotyrosine. Does not cross-react with phosphotyrosine.
Scientific Background: Tyrosine sulfation is a common post-translational protein modification catalyzed by tyrosylprotein sulfotransferase (TPST) (1). Sulfotyrosines mediate interactions between hirudin and thrombin, P-selectin glycoprotein ligand-1 and P-selectin, and von Willebrand factor and factor VIII. Tyrosine sulfation of certain receptors is required for several viruses and parasites to enter their hosts.
References: 1. Lee, R.W., Huttner W.B. (1983). J Biol Chem. 258(18):11326-34.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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