Abbreviation: TAB3
Target Synonym: MAP3K7IP3; NAP1
Conjugation: Unconjugated
UNIProt ID: Q8N5C8
Background: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TAB3
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
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