Formulation: A solid
Formal Name: (S)-N1-((6S,9S,12S,15S,18S,21S)-1-amino-22-((S)-2-(((2S,5S,8S,11S,14S,17S)-1-amino-2-benzyl-8,11-bis(3-guanidinopropyl)-18-(1H-imidazol-4-yl)-14-isobutyl-5-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaoctadecan-17-yl)carbamoyl)pyrrolidin-1-yl)-21-benzyl-9,12,15-tris(3-guanidinopropyl)-18-(hydroxymethyl)-1-imino-7,10,13,16,19,22-hexaoxo-2,8,11,14,17,20-hexaazadocosan-6-yl)-2-((2S,5S,8S,11S,14S,20S)-20-amino-8,11-bis(4-aminobutyl)-2,5,14-tris(3-guanidinopropyl)-21-(4-hydroxyphenyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazahenicosanamido)pentanediamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C125H212N54O24 • XCF3COOH
Formula Weight: 2855,4
Shelf life (days): 1460
Notes: Tat-NTS peptide is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to a 10-amino acid peptide corresponding to residues 228-237 of the repeat III domain of annexin A1, which functions as a nuclear translocation signal (NTS).{66518} It blocks the protein-protein interaction between annexin A1 and importin β, preventing nuclear translocation of annexin A1 in primary mouse hippocampal neurons.{66518} Tat-NTS inhibits glucose-oxygen deprivation and reperfusion-induced apoptosis in primary mouse hippocampal neurons. In vivo, Tat-NTS (10 mg/kg) reduces infarct size and neuronal apoptosis, as well as decreases the time to reach the platform in the Morris water maze test in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
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