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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: TBK1 (TANK-binding kinase 1) is a ubiquitously expressed serine/threonine kinase that belongs to the non-canonical IκB kinase (IKKs) family. TBK1 plays a critical role in controlling Type I interferon production through the IRF3 signaling pathway, suggesting it could be a promising drug target for autoimmune diseases such as interferonopathies.
Description: The TBK1 Assay Kit is designed to measure TBK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The TBK1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant TBK1 enzyme, TBK1 substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Fitzgerald K. A., et al., Nature Immunol, 2003, 4(5): 491-496
2. Ahmad L., et al., Trend Mol Med. 2016, 22(6): 511-527
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