Application Note: Anti-TFAM Antibody has been tested in Western Blots and is specific for the ~24 kDa TFAM protein. Specific conditions for reactivity should be optimized by the end user.
Concentration Value: Titrated for 10 miniBlots
ELISA Dilution: 1:20,000
Western Blot Dilution: 1:2000
General Disclaimer Note: This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen: Anti-TFAM Antibody was produced in rabbits by repeated immunizations with a native recombinant mouse TFAM protein with c-terminal 6-his tag.
Physical State: Liquid (sterile filtered)
Purity and Specificity: Anti-TFAM Antibody is a prepared sterile filtered neat serum.
Background: Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia. More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice. TFAM Antibody is ideal for researchers interested in neuroscience research.
Low Endotoxin: No
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