Clone Name: 2H11 + 6E1
Light Chain: Kappa
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 305
Positive Control: Thyroid
Specificity/Sensitivity: Clone [2H11 + 6E1] cocktail is especially designed for sensitive detection of thyroglobulin. It stains thyroglobulin in follicular epithelial cells as well as colloid tissue.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA, 0.09% Sodium azide.
Concentration:
Background: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Uniprot ID: P01266
Antigen Species: Human
Immunogen: Purified human thyroglobulin
Purification: unpurified
Conjugation: Unconjugated
Full Name: thyroglobulin
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