Description: Human recombinant TNFRSF10B produced in E.coli is a single, non-glycosylated, polypeptide chain containing 132 amino acids and having a molecular mass of 14.8kDa. TRAIL-Receptor-1 (DR4) and TRAIL-Receptor-2(DR5) are members of the TNFR superfamily of transmembrane proteins and contain a cytoplasmic 'death domain', which is capable of activating the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L.