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Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: Tropomyosin receptor kinase C (TRKC), also known as neurotrophic tyrosine kinase receptor type 3, is a member of the receptor tyrosine kinase family that mediates neurotrophin-activated signaling. TRKC is a functional coordinator in the activation of a host of signaling cascades including the mitogen-activated protein kinase (MAPK) pathway that leads to cell differentiation. Most recently, it has been shown that TRKC levels in hippocampal neurons dictate TRKC-mediated synapse density. TRKC expression levels are known to play a role in tumorigenesis as well as neurodegenerative diseases. Studies involving TRKC may lead to further understanding of disease pathology and to therapeutic treatments.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The Tropomyosin receptor kinase C (TRKC) Kinase Assay Kit is designed to measure TRKC kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant TRKC kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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