Abbreviation: TTLL12
Target Synonym: TTLL12; dJ526I14.2; tubulin tyrosine ligase like 12
Conjugation: Unconjugated
UNIProt ID: Q14166
Background: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TTLL12
Dilution: WB 1:500-1:2000