UBA1 Antibody - N-terminal region : Biotin

Conjugation: Biotin

Description of Target: UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UBA1

Key Reference: Ramser,J., (2008) Am. J. Hum. Genet. 82 (1), 188-193

Molecular Weight: 116kDa

Peptide Sequence: Synthetic peptide located within the following region: MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAV

Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.

Protein Name: Ubiquitin-like modifier-activating enzyme 1

Protein Size: 1058

Purification: Affinity Purified

• SKU: AVIARP58687_P050-Btn
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: ARP58687_P050-Biotin
• Package Unit: 100μl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine), Guinea Pig, Cow (Bovine), Horse (Equine)
• Clonality: Polyclonal
• Application: Western Blotting
• Human Gene ID: 7317
• Host: Rabbit
• Conjugate: Conjugated, Biotin