Conjugation: HRP: Horseradish Peroxidase
Description of Target: UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UBA1
Key Reference: Ramser,J., (2008) Am. J. Hum. Genet. 82 (1), 188-193
Molecular Weight: 116kDa
Peptide Sequence: Synthetic peptide located within the following region:
MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAVProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Ubiquitin-like modifier-activating enzyme 1
Protein Size: 1058
Purification: Affinity Purified
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