Target: ULK1.
Conjugate: ATTO 488.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the mid-protein of Human ULK1 (aa. 567-577).
Swiss-Prot: O75385.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~100 kDa.
Cellular Localization: Cytoplasm, Cytosol, Preautophagosomal Structure.
Tissue Specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Scientific Background: UNC-51 like kinase 1 (ULK1) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK1 is similar to ATG1, and it appears that both Atg1/ULK1 can bind to several ATG proteins regulating phosphorylation states and protein trafficking.
References: 1. Okazaki N., et al. (2000) Brain Res Mol Brain Res. 85: 1-12.2. Young A.R., et al. (2006) J Cell Sci. 119: 3888-900.3. Kamada Y., et al. (2000) J Cell Biol. 150: 1507-13.4. Lee S.B, et al. (2007) EMBO Rep. 8: 360-5.5. Hara T., et al. (2008) J Cell Biol. 181: 497-510.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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