Target: UT-A1.
Conjugate: Unconjugated.
Product Type: Polyclonal.
Immunogen: Produced against a synthetic peptide mapped to the C-terminal tail (amino acids 911-929) of rat UT-A1 (antibody designation L194).
Swiss-Prot: Q62668.
Purification: Protein A Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~97 and 127kDa.
Cellular Localization: Cell Membrane, Apical Cell Membrane.
Tissue Specificity: Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. Isoform 3 and isoform 4 are expressed in both the inner and outer renal medulla.
Scientific Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2) (1, 2).
References: 1. Nielsen S., et al. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500.2. Smith C.P. (2009) Exp Physiol. 94(2): 180-185.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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