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Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: ZAP70 (Zeta-chain-associated protein kinase-70) is a cytosolic tyrosine kinase expressed in immune cells such as T cells, NK cells, and a subset of B cells. It is recruited by the T Cell Receptor (TCR) upon activation by antigen binding to regulate gene expression and immune cell proliferation. Overexpression of ZAP70 has been observed in B cell malignancies, while patients with defects in ZAP70 have no functional T cells. Malfunctioning of ZAP70 appears to be involved in the onset of autoimmune diseases. ZAP70 is a close homolog to tyrosine kinase SYK, also involved in immune responses.
Description: The ZAP70 Kinase Assay Kit is designed to measure ZAP70 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant ZAP70 kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: P43403
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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