Abbreviation: ZNF207
Target Synonym: BuGZ; hBuGZ
Conjugation: Unconjugated
UNIProt ID: O43670
Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human ZNF207
Dilution: WB 1:1000-1:2000,IHC 1:50-1:200
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