1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride), CAS 428506-51-8

Formulation: A solid

Formal Name: N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monochloride

Purity: ≥95%

Formula Markup: C42H80NO4 • Cl

Formula Weight: 698,5

Shelf life (days): 730

CAS Number: 428506-51-8

Notes: 1,2-Dioleoyl-3(S)-trimethylammoniumpropane (S-DOTAP) is a cationic lipid and the less immunologically active isomer of DOTAP (Item No. 15110).{69270,69271} Lipoplexes containing S-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.{69270} Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in S-DOTAP-containing liposomes decrease tumor size but do not induce IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) in a murine cervical cancer model.{69271}

• SKU: CAY38195-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38195-100
• Package Unit: 100 mg
• Quantity Unit: STK
• Application: Reinstoffe