Formulation: A crystalline solid
Formal Name: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphatidylethanolamine
Purity: ≥95%
Formula Markup: C23H46NO7P
Formula Weight: 479,6
Shelf life (days): 1460
CAS Number: 89576-29-4
Notes: 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.{36851,36852,36853} It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid receptor 1 (LPA1) antagonist AM095 (Item No. 22141).{36852} 1-Oleoyl-2-hydroxy-sn-glycero-3-PE (100 ng/ml) increases IL-2 production in CD1d-stimulated murine natural killer T (NKT) cell hybridoma 2H4 cells.{36853} It also induces production of IL-4, but not IFN-γ, in murine splenocytes when used at a concentration of 100 ng/ml and in mouse serum when administered at a dose of 1 μg per animal, indicating induction of the T helper 2 (Th2) response. 1-Oleoyl-2-hydroxy-sn-glycero-3-PE levels increase in interscapular brown adipose tissue (iBAT) in mice following three-day cold exposure.{36851}
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