Formulation: A solution in methyl acetate
Formal Name: tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetrapropionate
Purity: ≥98%
Formula Markup: C57H111N3O8S8
Formula Weight: 1223
Shelf life (days): 730
CAS Number: 2803699-72-9
Notes: 113-O12B is a disulfide bond-containing ionizable cationic lipidoid.{65448} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.
English
Deutsch
