Formulation: A solid
Formal Name: (5R,7R,8R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-dihydroxyoctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11]pentaoxa[2,10]diphosphacyclotetradecine-2,10-bis(olate)-4,4,5,12,12,12a,15a,16-d8 2,10-dioxide, diammonium salt
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C20H14D8N10O13P2 • 2NH4
Formula Weight: 716,5
Shelf life (days): 1095
Notes: 2’3’-cGAMP-d8 is intended for use as an internal standard for the quantification of 2’3’-cGAMP (Item No. 19887) by GC- or LC-MS. 2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of dsDNA.{22401,22400,29220} It contains a non-canonical 2’5’-phosphodiester bond and binds tightly to the adapter protein stimulator of interferon genes (STING) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2’2’-cGAMP (Item No. 22419), 3’3’-cGAMP (Item No. 17966), cyclic di-GMP (Item No. 17144), and 3’2’-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively).{29220} It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.{29220}
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