Formulation: A solution in water
Formal Name: 2′(or 3′)-[2-(methylamino)benzoate] guanosine 5′-(trihydrogen diphosphate), trisodium salt
Purity: ≥95% (mixture of isomers)
Formula Markup: C18H19N6O12P2 • 3Na
Formula Weight: 642,3
Shelf life (days): 730
Notes: 2'-O-(N'-Methylanthraniloyl)guanosine-5'-O-diphosphate (2’-MANT-GDP) and 3’-MANT-GDP are fluorescent GDP derivatives, which undergo spontaneous isomerization.{67344} 2’(3’)-MANT-GDP selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, AC6, and bovine lung soluble guanylyl cyclase (sGC; Kis = 430, 2,600, 510, 320, and 4,200 nM, respectively) over B. anthracis edema factor AC toxin, rat testis soluble AC (sAC), and B. pertussis AC toxin (Kis = 37, 48, and 60 µM, respectively). 2’(3’)-MANT-GDP has been used to quantify guanine nucleotide exchange of GTPases.{66402} A related derivative, 2'(3')-MANT-GTP (Item No. 38469), displays an emission maximum of 442 nm upon excitation at 350 nm.{67581}
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