Product Type: Inhibitor
CAS No.: 524-95-8
MolecularFormula: C14H16BNO
Molecular Weight: 225,1
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
Appearance: White solid
PubChem CID: 1598
Scientific Background: 2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
References: 1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-3292. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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