Formulation: A crystalline solid
Formal Name: 2-(cyclohexylmethyl)-5-hydroxynaphthalene-1,4-dione
Purity: ≥95%
Formula Markup: C17H18O3
Formula Weight: 270,3
Shelf life (days): 730
Notes: 2-(cyclohexylmethyl)-Plumbagin is a derivative of the naphthoquinone plumbagin (Item No. 14314).{51400} It is selectively cytotoxic to PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, which mimic the microenvironment of pancreatic cancer tumors, over PANC-1 cells under nutrient-rich conditions with 50% preferential cytotoxicity values (PC50s) of 0.11 and 47.2 µM, respectively. It also induces apoptosis in PANC-1 cells when used at a concentration of 1 µM. 2-(cyclohexylmethyl)-Plumbagin also selectively reduces phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient-deprived, but not nutrient-rich, conditions. It reduces tumor volume and weight in a MiaPaCa-2 pancreatic cancer mouse xenograft model when administered at doses of 50 and 250 µg/animal five times per week.
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