Notes: 2’-Fluoro-2’-deoxyadenosine is a prodrug form of the cytotoxic purine nucleoside 2-fluoro-adenine.{72259} In vivo, 2’-fluoro-2’-deoxyadenosine (100 mg/kg) reduces mean tumor weight in an E. coli purine nucleoside phosphorylase-expressing D54 glioblastoma mouse xenograft model.