Formulation: A crystalline solid
Purity: ≥95%
Formula Markup: C8H8O3
Formula Weight: 152,1
Shelf life (days): 1460
CAS Number: 673-22-3
Notes: 2-Hydroxy-4-methoxybenzaldehyde is a phenol found in P. sepium that has diverse biological activities.{55018,55019,55020} It is active against Gram-positive (MICs = 100-200 µg/ml) and Gram-negative bacteria (MICs = 125-200 µg/ml), as well as the fungus C. albicans (MIC = 150 µg/ml).{55018} 2-Hydroxy-4-methoxybenzaldehyde scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay (IC50 = 9.04 mg/ml) and acts as a metal chelator, inhibiting ferrozine-Fe2+ complex formation with an IC50 value of 2.31 mg/ml. It reduces production of the virulence factor staphyloxanthin in clinical isolates of methicillin-resistant S. aureus (MRSA) when used at a concentration of 200 µg/ml and decreases the expression of the MRSA virulence regulatory genes saeS, geh, crtM, and sigB.{55019} 2-Hydroxy-4-methoxybenzaldehyde, when used in combination with the antibiotics amikacin (Item No. 15405), gentamicin, cefotaxime (Item No. 16040), vancomycin (Item No. 15327), or tetracycline (Item No. 14328), increases MRSA antibiotic sensitivity. It is also an intermediate in the synthesis of Schiff base-metal complexes with antiproliferative activity.{55020}
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