2BAct, CAS 2143542-28-1

Formulation: A solid

Formal Name: N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-2-pyrazinecarboxamide

Purity: ≥98%

Formula Markup: C19H16ClF3N4O3

Formula Weight: 440,8

Shelf life (days): 1460

CAS Number: 2143542-28-1

Notes: 2BAct is an activator of eukaryotic translation initiation factor 2B (eIF2B; EC50 = 33 nM in a reporter assay).{69170} It enhances eIF2B activity in primary fibroblasts isolated from Eif2b5R191H mutant (R191H) mouse embryos (EC50 = 7.3 nM), a model of vanishing white matter (VWM) leukodystrophy. In vivo, 2BAct (30 mg/kg) normalizes body weight gain and prevents the development of motor deficits in R191H mice. It also prevents activation of the integrated stress response and myelin loss in the same model.

• SKU: CAY37788-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37788-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe