Formulation: A solution in methyl acetate
Formal Name: bis(2-(octyldisulfaneyl)ethyl) 3,3'-((2-(methyl(3-(2-(octyldisulfaneyl)ethoxy)-3-oxopropyl)amino)ethyl)azanediyl)dipropionate
Purity: ≥95%
Formula Markup: C42H82N2O6S6
Formula Weight: 903,5
Shelf life (days): 365
Notes: 2N12B is a disulfide bond-containing ionizable cationic lipid (pKa = 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.{51816} LNPs containing 2N12B and encapsulating siRNA targeting VEGFA mRNA reduce VEGFA levels in ARPE-19 retinal pigment cells, as well as reduce migration of human umbilical vein endothelial cells (HUVECs) in a wound healing assay. LNPs containing 2N12B and encapsulating siRNA targeting Vegfa mRNA reduce Vegfa levels in isolated mouse retina, as well as inhibit retinal angiogenesis and decrease fundus vessel leakage, in a mouse model of oxygen-induced retinopathy.
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