Formulation: A solid
Formal Name: 5-hydroxy-4-methoxy-6H-indolo[3,2,1-de][1,5] naphthyridin-6-one
Purity: ≥98%
Formula Markup: C15H10N2O3
Formula Weight: 266,3
Shelf life (days): 1460
CAS Number: 18110-86-6
Notes: 4-methoxy-5-Hydroxycathin-6-one is an alkaloid that has been found in P. quassioides and has anti-inflammatory activity.{67646,67647} It reduces LPS-induced TNF-α release from, and nitric oxide (NO) production in, RAW 264.7 macrophages when used at concentrations of 10, 30, and 100 µM.{67646} In vivo, 4-methoxy-5-hydroxycathin-6-one (9 and 27 mg/kg) reduces paw swelling in a rat model of arthritis induced by complete Freund’s adjuvant (CFA). It also reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in wild-type, but not Fxr-/-, mice in a model of colitis induced by the sulfated polysaccharide dextran sulfate sodium (DSS; Item No. 23250) when administered at doses ranging from 25 to 100 mg/kg.{67647}
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