Formulation: A crystalline solid
Formal Name: 3,4-dihydro-4-thioxo-2(1H)-pyrimidinone
Purity: ≥98%
Formula Markup: C4H4N2OS
Formula Weight: 128,1
Shelf life (days): 1460
CAS Number: 591-28-6
Notes: 4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.{29954} It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm.{29955} 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.{29956}
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