Formulation: A solid
Formal Name: 5-[(3,4-dihydroxyphenyl)methyl]dihydro-2(3H)-furanone
Purity: ≥95%
Formula Markup: C11H12O4
Formula Weight: 208,2
Shelf life (days): 1460
CAS Number: 21618-92-8
Notes: 5-(3’,4’-Dihydroxyphenyl)-γ-valerolactone is an active metabolite of various polyphenols, including (–)-epicatechin (Item No. 11807) and procyanidin (Item No. 29763).{64771,64772} It is formed from these polyphenols by gut microbiota. 5-(3’,4’-Dihydroxyphenyl)-γ-valerolactone is an inhibitor of matrix metalloproteinase-1 (MMP-1) and MMP-2 collagen degradation activity (IC50s = 108 and 106 nM, respectively), MMP-1 and MMP-9 gelatin degradation activity (IC50s = 45.2 and 17.7 nM, respectively), and MMP-2 and MMP-9 elastin degradation activity (IC50s = 61.8 and 89 nM, respectively).{64773} It also scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{64771}
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