Product Type: Inhibitor
CAS No.: 320-67-2
MolecularFormula: C8H12N4O5
Molecular Weight: 244,2
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble in 25 mg/ml DMSO or 12 mg/ml Water
Appearance: White Solid
PubChem CID: 9444
Scientific Background: DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
References: 1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536.2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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