Formulation: A solid
Formal Name: 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Purity: ≥95%
Formula Markup: C21H31N5O3
Formula Weight: 401,5
Shelf life (days): 1460
CAS Number: 125481-61-0
Notes: 6-hydroxy Buspirone is an active metabolite of the anxiolytic buspirone.{72111,72112,72113} It is formed from buspirone by the cytochrome P450 (CYP) isoform CYP3A4.{64121} 6-hydroxy Buspirone binds to the serotonin (5-HT) receptor subtype 5-HT1A in rat hippocampus and dorsal raphe (EC50s = 4 and 1 µM, respectively) and is a dopamine D2, D3, and D4 receptor antagonist (IC50s = 3.1, 4.9, and 0.85 µM, respectively).{72111,72112} It also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 in S2 proximal tubule cells expressing the human transporters in a concentration-dependent manner.{72113}
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