Formulation: A solution in water
Formal Name: 6-thio-guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Purity: ≥98%
Formula Markup: C10H12N5O13P3S • 4Na
Formula Weight: 627,2
Shelf life (days): 780
Notes: 6-Thioguanosine-5’-O-triphosphate (6-thio-GTP) is an active metabolite of the purine analog 6-thioguanine (Item No. 15774) and the immunosuppressive purine analog azathioprine (Item No. 13987).{51291,51292} It is formed from 6-thioguanine via 6-thio-GMP and 6-thio-GDP intermediates by phosphorylation and from azathioprine via 6-mercaptopurine (Item No. 23675), 6-thio-GMP, and 6-thio-GDP intermediates by a non-enzymatic process and several enzymatic reactions. 6-thio-GTP binds to a variety of GTPases, including Rac, Ras, Cdc42, and RhoA but selectively inhibits activation of Rac1 and Rac2 over Cdc42 in primary human CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies.{66376,66377} It inhibits T cell receptor-stimulated proliferation of T cells and reduces CD28-dependent T cell survival in vitro in isolated mouse splenocytes.{66378} 6-Thio-GTP (0.5 mg/kg) increases survival in a mouse model of heart transplantation.
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