Product Type: Inhibitor
CAS No.: 667463-62-9
MolecularFormula: C16H10BrN3O2
Molecular Weight: 356,2
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble to 10 mM in DMSO and to 10 mM in ethanol
Appearance: Dark red solid
PubChem CID: 11405589
Scientific Background: 6BIO is an inhibitor of phosphoinositide-dependent kinase 1 (PDK1), and a potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). It maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway.
References: 1. Valerio A., et al. (2011) J. Neurochem. 116(6): 1148–1159.2. Yasuhara R., et al. (2010) J. Biol. Chem. 285(1): 317–327. 3. Meijer L., et al. (2003) Chem. & Bio. 10(12): 1255–1266.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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