7-Aminocephalosporanic Acid, CAS 957-68-6

Formulation: A solid

Formal Name: (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Purity: ≥98%

Formula Markup: C10H12N2O5S

CAS Number: 957-68-6

Notes: 7-Aminocephalosporanic acid (7-ACA) is a building block of cephalosporin antibiotics, including cephalosporin C (Item No. 33262) and cefapirin (Item No. 17406).{65957,65958} It binds to heat shock protein 90β (Hsp90β; Kd = 6.201 µM) and inhibits sterol regulatory element binding protein (SREBP) activation in a reporter assay using Hl 7702 cells when used at a concentration of 40 µM.{65959} 7-ACA (40 µM) inhibits increases in total cholesterol and triglyceride levels induced by palmitic acid (Item No. 10006627) and oleic acid (Item Nos. 90260 / 24659) in HepG2 cells. It reduces hepatic steatosis in mice fed a high-fat diet when administered at doses ranging from 5 to 25 mg/kg. 7-ACA (10 mg/kg) inhibits the growth of M. leprae in mice.{65960} It is also a potential impurity in commercial preparations of cefoperazone.{65961}

• SKU: CAY35824-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35824-5
• Green Labware: No
• Package Unit: 5 g
• Quantity Unit: STK