Product Type: Inhibitor
CAS No.: 1170613-55-4
MolecularFormula: C12H14FNO
Molecular Weight: 207,3
Source: Synthetic
Purity: >98%
Solubility: Soluble in DMSO (25 mg/ml)
Appearance: White solid
PubChem CID: 42641861
Scientific Background: A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2).
References: 1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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