Scientific Background: A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.
References: 1. Li W., et al. (2009) Stem Cell 4(1): 16–19. 2. Cherukuri P., et al. (2012). PloS One. 7(11): e50066.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.