Abbreviation: ABCB4
Target Synonym: ABCB4;ABC21;GBD1;ICP3;MDR2;MDR2/3;MDR3;PFIC-3;PGY3
Conjugation: Unconjugated
UNIProt ID: P21439
Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human ABCB4
Dilution: WB 1:500-1:2000
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