Notes: Acetamiprid-d3 is intended for use as an internal standard for the quantification of acetamiprid (Item No. 24129) by GC- or LC-MS. Acetamiprid is a neonicotinoid insecticide that acts as an agonist of insect nicotinic acetylcholine receptors (nAChRs).{42008} It activates nAChRs containing N. lugens α1 and rat β2 subunits with an EC50 value of 67 µM in X. laevis oocytes. Acetamiprid administered to pregnant mice at a dose of 1 mg/kg leads to sexual and aggressive behaviors in adult male offspring while doses of 1 and 10 mg/kg decrease anxiety-like behavior of adult male offspring in the light-dark transition test.{42009} Formulations containing acetamiprid have been used to control sucking insects on crops and pets.