Target: Acetylated Lysine
Conjugate: RPE
Product Type: Monoclonal
Clone Number: 7F8
Immunogen: Acetylated KLH
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects proteins containing acetylated lysine residues in ELISA and western blots. Does not detect non-acetylated lysine residues.
Cellular Localization: Nucleus
Scientific Background: Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε development (5).
References: 1. Yang XJ. (2005). Oncogene. 24:1653-1662.2. Hassig, C.A. and Schreiber, S.L. (1997). Curr. Opin. Chem. Biol. 1(3): 300-308.3. Yang XJ. (2004). Bioessays 26:1076-1087.4. Hughes, R.E. (2002). Curr. Biol. 12: R141-R143.5. Vigushin, D.M. and Coombes, R.C. (2004). Curr. Cancer Drug Targets 4: 205-218.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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