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Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: ADAM10 or ADAM Metallopeptidase Domain 10, is an enzyme that is involved in a diverse array of signaling pathways. It is part of the ADAM family of disintegrins and metalloproteases. It also plays a role in inflammatory disease and cancer.
Description: The key to the ADAM10 Fluorogenic Assay Kit is the fluorogenic substrate. Using this kit, only one simple step on a microtiter plate is required for ADAM10 reactions. A sample containing ADAM10 is incubated in a reaction mixture with the fluorogenic substrate and fluorescence (λex=485±10 nm, λem=530±10 nm) is measured using a plate reader.
Storage Stability: One year from date of receipt when stored as directed.
Supplied As: The ADAM10 Fluorogenic Assay Kit is provided in a convenient 96-well format, with purified ADAM10, ADAM Fluorogenic Substrate, and ADAM assay buffer for 96 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Scheller, J., et al. 2011. "ADAM10: a molecular switch to control inflammation and tissue regeneration." Trends in Immunology 32(8): 380-387.
2. Blaydon, D.C., et al. 2011. "Inflammatory skin and bowel disease linked to ADAM10 deletion." New England Journal of Medicine 365(16): 1502-1508.
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