Adenosine Receptor A2A Monoclonal Antibody (Clone 7F6-G5-A2)

Formulation: 500 µg affinity-purified monoclonal antibody

Immunogen: Human full length A2AR; the antibody recognizes amino acids 213-220 (SQPLPGER) as determined by epitope mapping

Clone Designation: 7F6-G5-A2

Shelf life (days): 1095

Notes: Adenosine receptor A2A Monoclonal Antibody (A2AR) is a multi-pass membrane protein that is normally localized to the plasma membrane.{15465} This receptor is part of the G protein-coupled receptor family that binds adenosine and serves multiple functions. Antagonists of this receptor have been targeted for the treatment of Parkinson’s disease.{15466,5049} Early reports found this receptor is found primarily in the brain striatum, but is also found in immune cells and other tissues as well.{15466} A2AR is comprised of 412 amino acids with an expected molecular weight of 45 kDa.{16148,15465} However multiple glycosylation sites exist that may explain the retarded migration observed by western blotting (45-50 kDa).{15465} This antibody has been extensively characterized and the epitope has been mapped to the third intracellular loop of the receptor.{16545}

• SKU: CAY10011454-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10011454-500
• Green Labware: No
• Package Unit: 1 ea (500 µg)
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Western Blotting
• Isotype: IgG2a
• Host: Mouse