Aftin-4, CAS 866893-90-5

Description: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

CAS Number: 866893-90-5

Formula: C20H28N6O

Molecular Weight: 368,48

References: Hochard A, etal. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease [J]. Journal of Alzheimers Disease Jad, 2013, 35(1):107-120.

• SKU: TGMT4364-200mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T4364-200mg
• Package Unit: 200 mg
• Quantity Unit: STK